Cecil's Textbook of Medicine: Principles of Drug Therapy: Pharmacokinetic Principles

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CECIL

TEXT BOOK of MEDICINE

Section V Clinical Pharmacology

27 PRINCIPLES OF DRUG THERAPY
	PHARMACOKINETIC PRINCIPLES
		Administration
		Absorption
		First-Pass Effect
		Bioavailability
		Distribution
		Volume of Distribution
		Elimination
	APPLYING PHARMACOKINETIC PRINCIPLES
		Using a Loading Dose
		Determining Drug Accumulation
		Using a Maintenance Dose
		Decreasing the Drug Level
	DOSE-DEPENDENT PHARMACOKINETICS
	MONITORING OF DRUG CONCENTRATION AS A GUIDE TO THERAPY
		Problems with Interpreting Drug Concentration
	ADJUSTING DRUG DOSE WITH DISEASE
		Kidney Disease
		Liver Disease
		Hemodynamic Diseases
	APPROACH TO DRUG OVERDOSE
	USING DRUGS IN THE ELDERLY
		Pharmacokinetic Changes with Age
		Pharmacodynamic Changes with Age
		General Recommendations
	INTERACTIONS BETWEEN DRUGS
			Epidemiology
			Etiology
			Diagnosis and Prevention of Drug Interactions
	ADVERSE REACTIONS TO DRUGS
			Epidemiology
			Etiology
			Diagnosis of Adverse Drug Responses